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Pateamine A

CAS No. 139220-18-1

Pateamine A( Pateamine )

Catalog No. M11628 CAS No. 139220-18-1

Pateamine A (Pateamine)?is a potent small molecule inhibitor of eukaryotic translation that stimulates eIF4AI/II and eIF4AIII activity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Pateamine A
  • Note
    Research use only, not for human use.
  • Brief Description
    Pateamine A (Pateamine)?is a potent small molecule inhibitor of eukaryotic translation that stimulates eIF4AI/II and eIF4AIII activity.
  • Description
    Pateamine A (Pateamine)?is a potent small molecule inhibitor of eukaryotic translation that stimulates eIF4AI/II and eIF4AIII activity, but not eIF4E, eIF2α, and elF4B; inhibits protein synthesis showing an IC50 of 5 nM in HeLa cells; prevents muscle wasting caused by IFNγ and TNFα or by C26-adenocarcinoma tumours in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Pateamine
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    eIF
  • Recptor
    eIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    139220-18-1
  • Formula Weight
    555.778
  • Molecular Formula
    C31H45N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1CC(CC(=O)OC(CC(=CC=CC(=O)OC(CC2=NC1=CS2)C=C(C)C=CC(=CCN(C)C)C)C)C)N
  • Chemical Name
    4,12-Dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraene-5,13-dione, 15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethyl-1,3,5-heptatrienyl]-9,11,17-trimethyl-, (3S,6Z,8E,11S,15R,17S)- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bordeleau ME, et al. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10460-5. 2. Di Marco S, et al. Nat Commun. 2012 Jun 12;3:896. 3. Popa A, et al. BMC Genomics. 2016 Jan 14;17:52.
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